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The ingress of antibiotics into the developing organism can provoke the development of fetal malformations, toxic damage to the central nervous system of the fetus. In the first trimester, it is advisable to avoid the use of antibiotics altogether. In the second and third trimesters, their appointment is safer, but also, if possible, should be limited.

It is impossible to refuse to prescribe antibiotics to a pregnant woman for the following diseases:

Pneumonia; angina; pyelonephritis; infected wounds; sepsis; specific infections: brucellosis, borrelliasis; genital infections: syphilis, gonorrhea. Penicillin, cephalosporin drugs, erythromycin, josamycin have almost no effect on the fetus. Penicillin, although it crosses the placenta, does not adversely affect the fetus. Cephalosporin and other named drugs cross the placenta in extremely low concentrations and are not able to harm the unborn child.

Conditionally safe drugs include metronidazole, gentamicin, and azithromycin.

They are prescribed only for health reasons, when the benefit to the woman outweighs the risk to the child. Such situations include severe pneumonia, sepsis, and other serious infections, in which a woman can simply die without antibiotics.

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aminoglycosides - can lead to congenital deafness (with the exception of gentamicin); clarithromycin, roxithromycin - in experiments, they had a toxic effect on animal embryos; fluoroquinolones; tetracycline - disrupts the formation of the skeletal system and teeth; chloramphenicol - dangerous in late pregnancy due to the suppression of the functions of the bone marrow in the child.

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The explanation is simple - no experiments are carried out on pregnant women to determine the toxicity of drugs. Experiments on animals, however, do not allow 100% certainty to exclude all negative effects, since the metabolism of drugs in humans and animals can differ significantly.

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It should be noted that before the planned pregnancy, you should also stop taking antibiotics or change your conception plans. Lisinopril drugs have a cumulative effect - they can accumulate in a woman's body, and for some time after the end of the course of treatment, they are gradually metabolized and excreted. It is recommended to get pregnant no earlier than 2-3 weeks after the end of the antibiotic intake.

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The ingestion of antibiotics into the human body leads not only to the destruction of pathogenic bacteria. Like all foreign chemicals, antibiotics have a systemic effect - in one way or another, they affect all systems of the body.

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There are several groups of antibiotic side effects: Almost any antibiotic can cause allergies. The severity of the reaction is different: a rash on the body, Quincke's edema (angioedema), anaphylactic shock. If an allergic rash is practically not dangerous, then anaphylactic shock can be fatal. The risk of shock is much higher with antibiotic injections, which is why injections should only be given in medical Lisinopril - there can be emergency care.

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Antibiotics and other antimicrobial drugs that cause cross-allergic reactions: Antibiotics can damage many organs, but the liver is most susceptible to their effects - against the background of antibiotic therapy, toxic hepatitis can occur. Certain drugs have a selective toxic effect on other organs: aminoglycosides - on the hearing aid (cause deafness); tetracyclines inhibit bone growth in children.

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Please note: the toxicity of the drug usually depends on its dose, but in case of individual intolerance, sometimes even smaller doses are enough for the effect to appear. When taking certain antibiotics, patients often complain of stomach pain, nausea, vomiting, and upset stools (diarrhea).

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These reactions are most often due to the local irritating effect of drugs. The specific effect of antibiotics on the intestinal flora leads to functional disorders of its activity, which is most often accompanied by diarrhea. This condition is called antibiotic-associated diarrhea, which is popularly known as dysbiosis after antibiotics.